Information on dosage, usage, side effects, interactions, and drug comparisons of Nabumetone.
Nabumetone
This page contains drug information on Nabumetone.
The information provided includes the following:
- what is Nabumetone
- the possible side effects of Nabumetone
- what happens if you miss a dose of Nabumetone
- what happens if you overdose with Nabumetone
- the most important information about Nabumetone
- how to use Nabumetone
- other drugs that may affect Nabumetone
- what to avoid while using Nabumetone
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Generic Name: Nabumetone
Brand Names: Nabumetone |
What is the most important information I should know about Nabumetone? |
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Rare cases of muscle problems and liver problems have been associated with the use of Nabumetone and other similar medicines. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, Nabumetone especially if accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. These may be early symptoms of muscle or liver problems. |
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Do not take Nabumetone without first talking to your doctor if you have liver disease. |
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Alcohol and Nabumetone can both be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined. |
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Do not take Nabumetone if you are pregnant, could become pregnant during treatment, or if you are breast-feeding a baby. |
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Nabumetone is an HMG CoA reductase inhibitor. Nabumetone blocks the production of cholesterol (a type of fat) in the body. |
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Nabumetone is used to reduce the total amounts of cholesterol, LDL (bad) cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) in your blood. Nabumetone (Nabumetone) is also used to increase the level of HDL (good) cholesterol in your blood. These actions may reduce the risk of hardening of the arteries, which can lead to heart attacks, stroke, and peripheral vascular disease. |
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Nabumetone may also be used for purposes other than those listed in this medication guide. |
What should I discuss with my healthcare provider before taking Nabumetone? |
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Do not take Nabumetone without first talking to your doctor if you have liver disease. |
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Before taking Nabumetone, tell your doctor if you |
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drink alcoholic beverages, |
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have a chronic muscular disease, or |
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You may not be able to take Nabumetone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. |
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Nabumetone is in the FDA pregnancy category X. This means that Nabumetone is known to cause birth defects if it is taken during pregnancy. Do not take Nabumetone if you are pregnant or could become pregnant during treatment. |
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It is not known whether Nabumetone passes into breast milk. Do not take Nabumetone without first talking to your doctor if you are breast-feeding a baby. |
How should I take Nabumetone? |
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Take Nabumetone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. |
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Take each dose with a full glass of water. |
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For the greatest effect, Nabumetone is usually taken at bedtime or with an evening meal. Follow your doctor's instructions. |
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Your doctor may want to monitor your liver function with blood tests before starting treatment with Nabumetone and every six months after both the start of your treatment and any increase in dose. Depending on the results of these tests, your doctor can determine how much monitoring you will require. |
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Grapefruit and grapefruit juice may interact with Nabumetone. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. |
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Eat a low-fat, low-cholesterol diet. To realize beneficial effects from Nabumetone, avoid fatty, high-cholesterol foods. |
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It is important to take Nabumetone regularly to get the most benefit. |
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Do not stop taking Nabumetone without first talking to your doctor. Nabumetone may need to be taken on a long-term basis for the treatment of high cholesterol. |
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Your doctor may want you to have blood tests or other medical evaluations during treatment with Nabumetone to monitor progress and side effects. |
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Store Nabumetone at room temperature away from moisture and heat. |
What happens if I miss a dose? |
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Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication. |
What happens if I overdose? |
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Seek emergency medical attention if an overdose is suspected. |
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Symptoms of a Nabumetone overdose include nausea, diarrhea, stomach distress, and indigestion. |
What should I avoid while taking Nabumetone? |
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Grapefruit and grapefruit juice may interact with Nabumetone. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. |
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Alcohol and Nabumetone can both be damaging to the liver. Alcohol should be used only in moderation. Discuss the use of alcohol with your doctor so that the potential for liver problems can be determined. |
What are the possible side effects of Nabumetone? |
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Rare cases of muscle problems and liver problems have been associated with the use of Nabumetone and other similar medicines. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if accompanied by a fever or flulike symptoms or yellowing of the skin or eyes, abdominal pain, unexplained fatigue, dark colored urine or pale colored stools. These may be early symptoms of muscle or liver problems. |
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If you experience any of the following serious side effects, stop taking Nabumetone and seek emergency medical attention or contact your doctor immediately: |
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an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); |
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decreased urine or rust-colored urine; or |
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Other, less serious side effects may be more likely to occur. Continue to take Nabumetone and talk to your doctor if you experience |
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gas, bloating, nausea, stomach upset, heartburn, abdominal pain, constipation, or diarrhea; |
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Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. |
What other drugs will affect Nabumetone? |
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Do not take Nabumetone without first talking to your doctor if you are taking any of the following medicines: |
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cyclosporine (Sandimmune, Neoral); |
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gemfibrozil (Lopid), clofibrate (Atromid-S), or fenofibrate (Tricor); |
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niacin (Nicolar, Nicobid, Slo-Niacin, others); |
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erythromycin (E-Mycin, E.E.S., Ery-Tab, others) or clarithromycin (Biaxin); |
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cholestyramine (Questran) or colestipol (Colestid); |
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an antifungal medication such as itraconazole (Sporanox), fluconazole (Diflucan), or ketoconazole (Nizoral); |
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digoxin (Lanoxin, Lanoxicaps); |
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a protease inhibitor such as amprenavir (Agenerase), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), lopinavir-ritonavir (Kaletra), or saquinavir (Invirase, Fortovase); |
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amiodarone (Cordarone, Pacer one); or |
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verapamil (Calan, Covera-HS, Isoptin, Verelan). |
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You may not be able to take Nabumetone, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above. |
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Drugs other than those listed here may also interact with Nabumetone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products. |
Where can I get more information? |
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Your pharmacist has additional information about Nabumetone written for health professionals that you may read. |
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. |
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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/ or to serve consumers viewing this service as a supplement to, andNabumetone side effects not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. |
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